E37* (p.Glu37Ter) variant of KRAS (GTPase KRas)
E37* (p.Glu37Ter) in KRAS (GTPase KRas) is a protein-truncating change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes experimental measurements, published literature, and structural context.
E37* (p.Glu37Ter) variant details
- p.Glu37Ter
- rs2135805697
- ClinGen CA384157210
- ClinVar RCV002292295
- Uncertain significance
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.654
- AlphaMissense 1.00
- MetaLR 0.69
- MetaSVM 0.52
- PolyPhen-2 0.37
- SIFT 0.02
- EVE 0.49
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.565
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)
- Cited in: Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline. (PMID 31829902)