E31* (p.Glu31Ter) variant of KRAS (GTPase KRas)
E31* (p.Glu31Ter) in KRAS (GTPase KRas) is a protein-truncating change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes experimental measurements, published literature, and structural context.
E31* (p.Glu31Ter) variant details
- p.Glu31Ter
- rs2135805818
- ClinGen CA384157274
- ClinVar RCV002292326
- Uncertain significance
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.496
- AlphaMissense 0.90
- MetaLR 0.52
- MetaSVM 0.07
- PolyPhen-2 0.97
- SIFT 0.00
- EVE 0.30
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.58
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)
- Cited in: Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline. (PMID 31829902)