D47G (p.Asp47Gly) variant of KRAS (GTPase KRas)
D47G (p.Asp47Gly) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes experimental measurements and structural context.
D47G (p.Asp47Gly) variant details
- p.Asp47Gly
- rs1565885006
- ClinGen CA384152371
- ClinVar RCV000781489
- Ensembl rs1565885006
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.592
- AlphaMissense 0.94
- MetaLR 0.61
- MetaSVM 0.23
- PolyPhen-2 0.36
- SIFT 0.00
- EVE 0.53
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.802