D33Y (p.Asp33Tyr) variant of KRAS (GTPase KRas)
D33Y (p.Asp33Tyr) in KRAS (GTPase KRas) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data, experimental measurements, and structural context.
D33Y (p.Asp33Tyr) variant details
- p.Asp33Tyr
- Ensembl rs2135805778
- Missense
- Variant Prioritization Score for Impact Estimate 0.808
- REVEL 0.85
- MetaLR 0.68
- MetaSVM 0.47
- CADD 27.80
- PolyPhen-2 0.99
- SIFT 0.01
- Population evidence available
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.603