D33E (p.Asp33Glu) variant of KRAS (GTPase KRas)
D33E (p.Asp33Glu) in KRAS (GTPase KRas) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, experimental measurements, and structural context.
D33E (p.Asp33Glu) variant details
- p.Asp33Glu
- NCI-TCGA Cosmic COSV5552
- cosmic curated COSV55525
- NCI-TCGA Cosmic COSV5581
- Ensembl rs2135805765
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.413
- REVEL 0.54
- MetaLR 0.40
- MetaSVM -0.32
- CADD 22.40
- PolyPhen-2 0.87
- SIFT 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.603