D154V (p.Asp154Val) variant of KRAS (GTPase KRas)
D154V (p.Asp154Val) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Neoplasm. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes experimental measurements and structural context.
D154V (p.Asp154Val) variant details
- p.Asp154Val
- rs989151052
- ClinGen CA384149261
- ClinVar RCV003330455
- TOPMed rs989151052
- Uncertain significance
- Neoplasm
- Missense
- Variant Prioritization Score for Impact Estimate 0.432
- AlphaMissense 0.63
- MetaLR 0.35
- MetaSVM -0.31
- PolyPhen-2 0.90
- SIFT 0.00
- EVE 0.27
- ClinVar: Uncertain significance (Neoplasm)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- binding fitness from KRAS-DARPin K27 bindingPCA of KRAS block3: score -0.125