A18D (p.Ala18Asp) variant of KRAS (GTPase KRas)
A18D (p.Ala18Asp) in KRAS (GTPase KRas) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.85 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A18D (p.Ala18Asp) variant details
- p.Ala18Asp
- NCI-TCGA Cosmic COSV5556
- NCI-TCGA Cosmic COSV5558
- cosmic curated COSV55580
- NCI-TCGA Cosmic COSV5571
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.845
- REVEL 0.88
- MetaLR 0.80
- MetaSVM 0.87
- CADD 28.40
- PolyPhen-2 0.98
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.152