L321F (p.Leu321Phe) variant of KLF4 (Krueppel-like factor 4)
L321F (p.Leu321Phe) in KLF4 (Krueppel-like factor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and published literature.
L321F (p.Leu321Phe) variant details
- p.Leu321Phe
- rs1059914
- UniProt VAR 059889
- Missense
- Variant Prioritization Score for Impact Estimate 0.171
- REVEL 0.07
- MetaLR 0.01
- MetaSVM -0.98
- CADD 23.00
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Literature evidence available