F15L (p.Phe15Leu) variant of JAK1 (Tyrosine-protein kinase JAK1)
F15L (p.Phe15Leu) in JAK1 (Tyrosine-protein kinase JAK1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
F15L (p.Phe15Leu) variant details
- p.Phe15Leu
- Ensembl rs2101267615
- Missense
- Variant Prioritization Score for Impact Estimate 0.437
- REVEL 0.33
- CADD 21.10
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available