R108* (p.Arg108Ter) variant of ITGA2B (Integrin alpha-IIb)
R108* (p.Arg108Ter) in ITGA2B (Integrin alpha-IIb) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
R108* (p.Arg108Ter) variant details
- p.Arg108Ter
- NCI-TCGA Cosmic COSV9928
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.391
- CADD 34.00
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available