T61R (p.Thr61Arg) variant of IRS2 (Insulin receptor substrate 2)
T61R (p.Thr61Arg) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
T61R (p.Thr61Arg) variant details
- p.Thr61Arg
- ExAC rs750038928
- TOPMed rs750038928
- gnomAD rs750038928
- Missense
- Variant Prioritization Score for Impact Estimate 0.326
- REVEL 0.02
- CADD 17.10
- PolyPhen-2 0.29
- SIFT 0.35
- Most common in the Non-Finnish European population (allele frequency 9.4e-07)
- Structural context available