T61M (p.Thr61Met) variant of IRS2 (Insulin receptor substrate 2)
T61M (p.Thr61Met) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
T61M (p.Thr61Met) variant details
- p.Thr61Met
- ExAC rs750038928
- TOPMed rs750038928
- gnomAD rs750038928
- Missense
- Variant Prioritization Score for Impact Estimate 0.374
- REVEL 0.07
- CADD 21.90
- PolyPhen-2 0.62
- SIFT 0.09
- Most common in the REMAINING population (allele frequency 1.8e-05)
- Structural context available