S66W (p.Ser66Trp) variant of IRS2 (Insulin receptor substrate 2)
S66W (p.Ser66Trp) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
S66W (p.Ser66Trp) variant details
- p.Ser66Trp
- Ensembl rs2138939417
- Missense
- Variant Prioritization Score for Impact Estimate 0.243
- REVEL 0.04
- CADD 23.70
- PolyPhen-2 0.48
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9.4e-07)
- Structural context available