S66L (p.Ser66Leu) variant of IRS2 (Insulin receptor substrate 2)
S66L (p.Ser66Leu) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
S66L (p.Ser66Leu) variant details
- p.Ser66Leu
- Ensembl rs2138939417
- Missense
- Variant Prioritization Score for Impact Estimate 0.232
- REVEL 0.06
- CADD 18.60
- PolyPhen-2 0.00
- SIFT 0.13
- Population evidence available
- Structural context available