S66A (p.Ser66Ala) variant of IRS2 (Insulin receptor substrate 2)
S66A (p.Ser66Ala) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
S66A (p.Ser66Ala) variant details
- p.Ser66Ala
- ExAC rs372367471
- gnomAD rs372367471
- Missense
- Variant Prioritization Score for Impact Estimate 0.137
- REVEL 0.01
- CADD 17.10
- PolyPhen-2 0.01
- SIFT 0.52
- Most common in the HGDP:RUSSIAN population (allele frequency 0.038)
- Structural context available