R51H (p.Arg51His) variant of IRS2 (Insulin receptor substrate 2)
R51H (p.Arg51His) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
R51H (p.Arg51His) variant details
- p.Arg51His
- TOPMed rs1877908226
- Missense
- Variant Prioritization Score for Impact Estimate 0.575
- REVEL 0.52
- CADD 24.30
- PolyPhen-2 0.62
- SIFT 0.00
- Most common in the East Asian population (allele frequency 6e-05)
- Structural context available