P9S (p.Pro9Ser) variant of IRS2 (Insulin receptor substrate 2)
P9S (p.Pro9Ser) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.05 / 1. The record also includes population frequency data and structural context.
P9S (p.Pro9Ser) variant details
- p.Pro9Ser
- TOPMed rs1409660082
- Missense
- Variant Prioritization Score for Impact Estimate 0.055
- REVEL 0.02
- CADD 3.38
- PolyPhen-2 0.01
- SIFT 0.78
- Most common in the Non-Finnish European population (allele frequency 6.1e-06)
- Structural context available