P70T (p.Pro70Thr) variant of IRS2 (Insulin receptor substrate 2)
P70T (p.Pro70Thr) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
P70T (p.Pro70Thr) variant details
- p.Pro70Thr
- gnomAD rs1415372702
- Missense
- Variant Prioritization Score for Impact Estimate 0.513
- REVEL 0.50
- CADD 23.10
- PolyPhen-2 0.39
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available