P70S (p.Pro70Ser) variant of IRS2 (Insulin receptor substrate 2)
P70S (p.Pro70Ser) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
P70S (p.Pro70Ser) variant details
- p.Pro70Ser
- gnomAD rs1415372702
- Missense
- Variant Prioritization Score for Impact Estimate 0.447
- REVEL 0.39
- CADD 23.10
- PolyPhen-2 0.19
- SIFT 0.01
- Population evidence available
- Structural context available