P68L (p.Pro68Leu) variant of IRS2 (Insulin receptor substrate 2)
P68L (p.Pro68Leu) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
P68L (p.Pro68Leu) variant details
- p.Pro68Leu
- 1000Genomes rs2138939394
- Missense
- Variant Prioritization Score for Impact Estimate 0.291
- REVEL 0.07
- CADD 22.60
- PolyPhen-2 0.01
- SIFT 0.24
- Most common in the 1KG:YRI population (allele frequency 0.0043)
- Structural context available