P18S (p.Pro18Ser) variant of IRS2 (Insulin receptor substrate 2)
P18S (p.Pro18Ser) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
P18S (p.Pro18Ser) variant details
- p.Pro18Ser
- TOPMed rs1877912292
- Missense
- Variant Prioritization Score for Impact Estimate 0.214
- REVEL 0.07
- CADD 14.10
- PolyPhen-2 0.01
- SIFT 0.81
- Most common in the Non-Finnish European population (allele frequency 9.8e-07)
- Structural context available