N27S (p.Asn27Ser) variant of IRS2 (Insulin receptor substrate 2)
N27S (p.Asn27Ser) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
N27S (p.Asn27Ser) variant details
- p.Asn27Ser
- Ensembl rs1877911659
- Missense
- Variant Prioritization Score for Impact Estimate 0.176
- REVEL 0.05
- CADD 15.00
- PolyPhen-2 0.00
- SIFT 0.82
- Most common in the African/African-American population (allele frequency 3.7e-05)
- Structural context available