L20H (p.Leu20His) variant of IRS2 (Insulin receptor substrate 2)
L20H (p.Leu20His) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
L20H (p.Leu20His) variant details
- p.Leu20His
- Ensembl rs2138939853
- Missense
- Variant Prioritization Score for Impact Estimate 0.163
- REVEL 0.09
- CADD 17.20
- PolyPhen-2 0.44
- SIFT 0.00
- Population evidence available
- Structural context available