L20F (p.Leu20Phe) variant of IRS2 (Insulin receptor substrate 2)
L20F (p.Leu20Phe) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
L20F (p.Leu20Phe) variant details
- p.Leu20Phe
- TOPMed rs1435824732
- gnomAD rs1435824732
- Missense
- Variant Prioritization Score for Impact Estimate 0.254
- REVEL 0.10
- CADD 16.70
- PolyPhen-2 0.00
- SIFT 0.02
- Most common in the Middle Eastern population (allele frequency 0.00039)
- Structural context available