K45R (p.Lys45Arg) variant of IRS2 (Insulin receptor substrate 2)
K45R (p.Lys45Arg) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
K45R (p.Lys45Arg) variant details
- p.Lys45Arg
- TOPMed rs921690150
- gnomAD rs921690150
- Missense
- Variant Prioritization Score for Impact Estimate 0.221
- REVEL 0.07
- CADD 22.50
- PolyPhen-2 0.02
- SIFT 0.17
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available