K45N (p.Lys45Asn) variant of IRS2 (Insulin receptor substrate 2)
K45N (p.Lys45Asn) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
K45N (p.Lys45Asn) variant details
- p.Lys45Asn
- TOPMed rs1381868281
- gnomAD rs1381868281
- Missense
- Variant Prioritization Score for Impact Estimate 0.396
- REVEL 0.42
- CADD 23.50
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available