K41R (p.Lys41Arg) variant of IRS2 (Insulin receptor substrate 2)
K41R (p.Lys41Arg) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
K41R (p.Lys41Arg) variant details
- p.Lys41Arg
- 1000Genomes rs2138939637
- Missense
- Variant Prioritization Score for Impact Estimate 0.283
- REVEL 0.21
- CADD 23.50
- PolyPhen-2 0.15
- SIFT 0.03
- Most common in the 1KG:PJL population (allele frequency 0.0052)
- Structural context available