K33R (p.Lys33Arg) variant of IRS2 (Insulin receptor substrate 2)
K33R (p.Lys33Arg) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
K33R (p.Lys33Arg) variant details
- p.Lys33Arg
- TOPMed rs1048711377
- Missense
- Variant Prioritization Score for Impact Estimate 0.421
- REVEL 0.34
- CADD 24.40
- PolyPhen-2 0.38
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 3.8e-06)
- Structural context available