K33M (p.Lys33Met) variant of IRS2 (Insulin receptor substrate 2)
K33M (p.Lys33Met) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
K33M (p.Lys33Met) variant details
- p.Lys33Met
- TOPMed rs1048711377
- Missense
- Variant Prioritization Score for Impact Estimate 0.576
- REVEL 0.58
- CADD 27.90
- PolyPhen-2 0.84
- SIFT 0.00
- Population evidence available
- Structural context available