H42Y (p.His42Tyr) variant of IRS2 (Insulin receptor substrate 2)
H42Y (p.His42Tyr) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
H42Y (p.His42Tyr) variant details
- p.His42Tyr
- TOPMed rs1877909468
- gnomAD rs1877909468
- Missense
- Variant Prioritization Score for Impact Estimate 0.374
- REVEL 0.26
- CADD 23.30
- PolyPhen-2 0.29
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 6.6e-05)
- Structural context available