H29Y (p.His29Tyr) variant of IRS2 (Insulin receptor substrate 2)
H29Y (p.His29Tyr) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
H29Y (p.His29Tyr) variant details
- p.His29Tyr
- TOPMed rs1037219199
- gnomAD rs1037219199
- Missense
- Variant Prioritization Score for Impact Estimate 0.189
- REVEL 0.03
- CADD 16.40
- PolyPhen-2 0.13
- SIFT 0.06
- Most common in the Latino/Admixed American population (allele frequency 0.0004)
- Structural context available