G8W (p.Gly8Trp) variant of IRS2 (Insulin receptor substrate 2)
G8W (p.Gly8Trp) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
G8W (p.Gly8Trp) variant details
- p.Gly8Trp
- TOPMed rs1348529090
- gnomAD rs1348529090
- Missense
- Variant Prioritization Score for Impact Estimate 0.229
- REVEL 0.10
- CADD 21.00
- PolyPhen-2 0.39
- SIFT 0.00
- Most common in the South Asian population (allele frequency 2.2e-05)
- Structural context available