G8R (p.Gly8Arg) variant of IRS2 (Insulin receptor substrate 2)
G8R (p.Gly8Arg) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
G8R (p.Gly8Arg) variant details
- p.Gly8Arg
- TOPMed rs1348529090
- gnomAD rs1348529090
- Missense
- Variant Prioritization Score for Impact Estimate 0.175
- REVEL 0.03
- CADD 18.70
- PolyPhen-2 0.00
- SIFT 0.01
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.9e-05)
- Structural context available