G65V (p.Gly65Val) variant of IRS2 (Insulin receptor substrate 2)
G65V (p.Gly65Val) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
G65V (p.Gly65Val) variant details
- p.Gly65Val
- TOPMed rs1293916243
- gnomAD rs1293916243
- Missense
- Variant Prioritization Score for Impact Estimate 0.187
- REVEL 0.03
- CADD 22.10
- PolyPhen-2 0.03
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 3e-05)
- Structural context available