G65E (p.Gly65Glu) variant of IRS2 (Insulin receptor substrate 2)
G65E (p.Gly65Glu) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
G65E (p.Gly65Glu) variant details
- p.Gly65Glu
- TOPMed rs1293916243
- gnomAD rs1293916243
- Missense
- Variant Prioritization Score for Impact Estimate 0.257
- REVEL 0.12
- CADD 23.80
- PolyPhen-2 0.80
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9.4e-07)
- Structural context available