G64W (p.Gly64Trp) variant of IRS2 (Insulin receptor substrate 2)
G64W (p.Gly64Trp) in IRS2 (Insulin receptor substrate 2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
G64W (p.Gly64Trp) variant details
- p.Gly64Trp
- NCI-TCGA Cosmic COSV1010
- ExAC rs756734259
- TOPMed rs756734259
- gnomAD rs756734259
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.328
- REVEL 0.19
- CADD 26.40
- PolyPhen-2 0.98
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.8e-06)
- Structural context available