G64R (p.Gly64Arg) variant of IRS2 (Insulin receptor substrate 2)
G64R (p.Gly64Arg) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
G64R (p.Gly64Arg) variant details
- p.Gly64Arg
- ExAC rs756734259
- TOPMed rs756734259
- gnomAD rs756734259
- Missense
- Variant Prioritization Score for Impact Estimate 0.303
- REVEL 0.16
- CADD 25.30
- PolyPhen-2 0.78
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available