G56D (p.Gly56Asp) variant of IRS2 (Insulin receptor substrate 2)
G56D (p.Gly56Asp) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
G56D (p.Gly56Asp) variant details
- p.Gly56Asp
- gnomAD rs1485515924
- Missense
- Variant Prioritization Score for Impact Estimate 0.235
- REVEL 0.12
- CADD 14.50
- PolyPhen-2 0.01
- SIFT 0.10
- Most common in the South Asian population (allele frequency 9.4e-05)
- Structural context available