G52R (p.Gly52Arg) variant of IRS2 (Insulin receptor substrate 2)
G52R (p.Gly52Arg) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
G52R (p.Gly52Arg) variant details
- p.Gly52Arg
- TOPMed rs1222652819
- Missense
- Variant Prioritization Score for Impact Estimate 0.461
- REVEL 0.39
- CADD 24.20
- PolyPhen-2 0.72
- SIFT 0.12
- Most common in the Non-Finnish European population (allele frequency 9.4e-07)
- Structural context available