G17R (p.Gly17Arg) variant of IRS2 (Insulin receptor substrate 2)
G17R (p.Gly17Arg) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
G17R (p.Gly17Arg) variant details
- p.Gly17Arg
- TOPMed rs1476561196
- gnomAD rs1476561196
- Missense
- Variant Prioritization Score for Impact Estimate 0.286
- REVEL 0.10
- CADD 23.50
- PolyPhen-2 0.74
- SIFT 0.03
- Most common in the Latino/Admixed American population (allele frequency 6.6e-05)
- Structural context available