G15R (p.Gly15Arg) variant of IRS2 (Insulin receptor substrate 2)
G15R (p.Gly15Arg) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
G15R (p.Gly15Arg) variant details
- p.Gly15Arg
- gnomAD rs1279752588
- Missense
- Variant Prioritization Score for Impact Estimate 0.201
- REVEL 0.06
- CADD 20.10
- PolyPhen-2 0.07
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 3e-06)
- Structural context available