G15E (p.Gly15Glu) variant of IRS2 (Insulin receptor substrate 2)
G15E (p.Gly15Glu) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
G15E (p.Gly15Glu) variant details
- p.Gly15Glu
- TOPMed rs895227588
- gnomAD rs895227588
- Missense
- Variant Prioritization Score for Impact Estimate 0.268
- REVEL 0.03
- CADD 20.30
- PolyPhen-2 0.02
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 4.9e-05)
- Structural context available