G15A (p.Gly15Ala) variant of IRS2 (Insulin receptor substrate 2)
G15A (p.Gly15Ala) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
G15A (p.Gly15Ala) variant details
- p.Gly15Ala
- TOPMed rs895227588
- gnomAD rs895227588
- Missense
- Variant Prioritization Score for Impact Estimate 0.279
- REVEL 0.06
- CADD 19.10
- PolyPhen-2 0.01
- SIFT 0.02
- Most common in the Middle Eastern population (allele frequency 0.00021)
- Structural context available