G11R (p.Gly11Arg) variant of IRS2 (Insulin receptor substrate 2)
G11R (p.Gly11Arg) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
G11R (p.Gly11Arg) variant details
- p.Gly11Arg
- Ensembl rs2138939958
- Missense
- Variant Prioritization Score for Impact Estimate 0.164
- REVEL 0.03
- CADD 10.70
- PolyPhen-2 0.04
- SIFT 0.09
- Most common in the Non-Finnish European population (allele frequency 2e-06)
- Structural context available