D58E (p.Asp58Glu) variant of IRS2 (Insulin receptor substrate 2)
D58E (p.Asp58Glu) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
D58E (p.Asp58Glu) variant details
- p.Asp58Glu
- Ensembl rs2138939498
- Missense
- Variant Prioritization Score for Impact Estimate 0.103
- REVEL 0.04
- CADD 15.30
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the African/African-American population (allele frequency 3.5e-05)
- Structural context available