A55T (p.Ala55Thr) variant of IRS2 (Insulin receptor substrate 2)
A55T (p.Ala55Thr) in IRS2 (Insulin receptor substrate 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
A55T (p.Ala55Thr) variant details
- p.Ala55Thr
- gnomAD rs1877907525
- Missense
- Variant Prioritization Score for Impact Estimate 0.113
- REVEL 0.02
- CADD 13.40
- PolyPhen-2 0.01
- SIFT 0.35
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available