Y18H (p.Tyr18His) variant of IRS1 (Insulin receptor substrate 1)
Y18H (p.Tyr18His) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.73 / 1. The record also includes population frequency data.
Y18H (p.Tyr18His) variant details
- p.Tyr18His
- TOPMed rs1939814464
- Missense
- Variant Prioritization Score for Impact Estimate 0.734
- REVEL 0.77
- CADD 32.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 4.8e-05)