S99G (p.Ser99Gly) variant of IRS1 (Insulin receptor substrate 1)
S99G (p.Ser99Gly) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data.
S99G (p.Ser99Gly) variant details
- p.Ser99Gly
- TOPMed rs1559160175
- Missense
- Variant Prioritization Score for Impact Estimate 0.633
- REVEL 0.63
- CADD 26.90
- PolyPhen-2 0.63
- SIFT 0.03
- Most common in the HGDP:YAKUT population (allele frequency 0.04)