S68R (p.Ser68Arg) variant of IRS1 (Insulin receptor substrate 1)
S68R (p.Ser68Arg) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data.
S68R (p.Ser68Arg) variant details
- p.Ser68Arg
- TOPMed rs1460898587
- gnomAD rs1460898587
- Missense
- Variant Prioritization Score for Impact Estimate 0.625
- REVEL 0.50
- CADD 28.70
- PolyPhen-2 0.99
- SIFT 0.01
- Most common in the Middle Eastern population (allele frequency 0.0007)