S58R (p.Ser58Arg) variant of IRS1 (Insulin receptor substrate 1)
S58R (p.Ser58Arg) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data.
S58R (p.Ser58Arg) variant details
- p.Ser58Arg
- TOPMed rs942929290
- Missense
- Variant Prioritization Score for Impact Estimate 0.486
- REVEL 0.27
- CADD 27.10
- PolyPhen-2 0.86
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00019)